連携大学院 ― 入学志望者の方へ
辻研究室
Tsuji Laboratory
業 績
| 原著論文(2001年以降) | 原著論文(2000年以前) | 特 許 |
原著論文(2001年以降)
- Alim MA, Tsuji N, Miyoshi T, Islam MK, Hatta T, Fujisaki K. (2008). Legumains from the hard tick Haemaphysalis longicornis play modulatory roles in blood feeding and gut cellular remodeling and impact on embryogenesis. Int J Parasitol. 38. in press.
- Yoshihara S, Hattori J, Nishizono K, Kawamura A, Shinozuka K, Nishida Y, Oda K, Tsuji N, Hirayama N. (2008). Hepatic lesions caused by migrating larvae of Ascaris suum in chickens. J Vet Med Sci. 70. in press.
- Tsuji N, Miyoshi T, Badger B, Matsuo T, Xuan X, Fujisaki K. (2008). A cysteine protease is critical for Babesia spp. transmission in Haemaphysalis ticks. PLoS Pathog. 4, e1000062.
- Alim MA, Tsuji N, Miyoshi T, Islam MK, Huang X, Hatta T, Fujisaki K. (2008) HlLgm2, a member of asparaginyl endopeptidases/legumains in the midgut of the ixodid tick Haemaphysalis longicornis is involved in blood-meal digestion. J Insect Physiol. 54, 573-585.
- Iwata F, Shinjyo N, Amino H, Sakamoto K, Islam MK, Tsuji N, Kita K. (2008). Change of subunit composition of mitochondrial complex II (Succinate-ubiquinone reductase/Quinol-fumarate reductase) in Ascaris suum during the migration in the host. Parasitol Int. 57, 54-61.
- Tsuji N, Fujisaki K. (2007). Longicin plays crucial role for the transmission of Babesia parasites in the vector tick Haemaphysalis longicornis. Future Microbiol. 2,575-578.
- Damdinsuren B, Badger B, Hatta T, Miyoshi T, Tsuji N, Xuan X, Fujisaki K. (2007). Valosin- containing protein from the hard tick Haemaphysalis longicornis: effects of dsRNA-mediated HlVCP gene silencing. Biochem Cell Biol. 85, 384-394.
- Alim MA, Tsuji N, Miyoshi T, Huang X, Islam MK, Motobu M, Fujisaki K. (2007). Characterization of asparaginyl endopeptidase, legumain induced by blood feeding in the ixodid tick Haemaphysalis longicornis. Insect Biochem Mol Biol. 37, 911-922.
- Tsuji N, Badger B, Damdinsuren B, Miyoshi T, Xuan X, Oliver Jr JH, Fujisaki K. (2007). Babesial vector tick defensin against Babesia sp. parasites. Infect Immune. 75, 3633-3640.
- Motobu M, Tsuji N, Miyoshi T, Huang X, Islam MK, Alim MA, Fujisaki K. (2007). Molecular characterization of a blood-induced serine carboxypeptidase from the ixodid tick Haemaphysalis longicornis. FEBS J. 274, 3299-3312.
- Liao M, Zhou J, Hatta T, Umemiya R, Miyoshi T, Tsuji N, Xuan X, Fujisaki K. (2007). Molecular characterization of Rhipicephalus (Boophilus) microplus Bm86 homologue from Haemaphysalis longicornis ticks. Vet Parasitol 146, 148-57.
- Miyoshi T, Tsuji N Islam MK, Huang X, Motobu M, Alim MA, Fujisaki K. (2007) Molecular and reverse genetic characterization of serine proteinase-induced hemolysis in the midgut of the ixodid tick Haemaphysalis longicornis J Insect Physiol 53, 195-203.
- Huang X, Tsuji N, Miyoshi T, Motobu M, Islam MK, Alim MB, Fujisaki K. (2007) Characterization of glutamine: Fructose-6-phosphate aminotransferase from the ixodid tick, Haemaphysalis longicornis, and its critical role in host blood feeding. Int J Parasitol. 37. 383-392.
- Huang X, Tsuji N, Miyoshi T, Nakamura-Tsuruta S, Hirabayashi J, Fujisaki K. (2007) Molecular characterization and oligosaccharide binding properties of a galectin from the argasid tick Ornithodoros moubata. Glycobiology 17, 313-323.
- Hatta T, Umemiya R, Liao M, Gong H, Harnnoi T, Tanaka M, Miyoshi T, Boldbaatar D, Battsetseg B, Zhou J, Xuan X, Tsuji N, Taylor D, Fujisaki K.(2007) RNA interference of cytosolic leucine aminopeptidase reduces fecundity in the hard tick, Haemaphysalis longicornis. Parasitol Res 100, 847-854.
- Hikosaka K, Koyama Y, Motobu M, Yamada M, Nakamura K, Koge K, Shimura K, Isobe T, Tsuji N, Kang CB, Hayashidani H, Wang PC, Matsumura M, Hirota Y. (2006) Reduced lipopolysaccharide (LPS)-induced nitric oxide production in peritoneal macrophages and inhibited LPS-induced lethal shock in mice by a sugar cane (Saccharum officinarum L.) extract. Biosci Biotechnol Biochem. 70, 2853-2858.
- Islam MK, Miyoshi T, Yamada M, Alim MA, Huang X, Motobu M, Tsuji N. (2006) Effect of piperazine (diethylenediamine) on the moulting, proteome expression and pyrophosphatase activity of Ascaris suum lung-stage larvae. Acta Tropica. 99, 208-217.
- Hatta T, Kazama K, Miyoshi T, Umemiya R, Liao M, Inoue N, Xuan X, Tsuji N, Fujisaki K. (2006) Identification and characterisation of a leucine aminopeptidase from the hard tick Haemaphysalis longicornis. Int J Parasitol. 36, 1123-32.
- Islam MK, Miyoshi T, Yamada M, Alim MA, Huang X, Motobu M, Tsuji N.(2006) Fluoride exposure inhibits protein expression and enzyme activity in the lung-stage larvae of Ascaris suum. Parasitology 133, 497-508.
- Islam MK, Alim MA, Tsuji N, Mondal MMH. (2006) An Investigation into the Distribution, Host-preference and Population Density of Ixodid Ticks Affecting Domestic Animals in Bangladesh. Trop Anim Hlth Prod. 38, 485-490.
- Arakawa T, Komesu A, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, and Tsuboi T (2005) Nasal immunization with a malaria transmission-blocking vaccine candidate Pfs25 induces complete protective immunity in mice against field-isolated Plasmodium falciparum. Infect Immun 73, 7375-7380.
- Islam MK, Miyoshi T, Tsuji N. (2005).Vaccination with recombinant Ascaris suum 24-kilodalton antigen induces a Th1/Th2-mixed type immune response and confers high levels of protection against challenged A. suum lung-stage infection in BALB/c mice. Int J Parasitol 35, 1023-1030.
- Islam MK, Miyoshi T, Yamada M, Tsuji N. (2005). The roundworm Ascaris suum pyrophosphatase plays an essential role in worm’s molting and development. Infect Immun. 73, 1995-2004.
- Islam MK, Miyoshi T, Yokomizo Y, Tsuji N. (2005). Molecular cloning and partial characterization of a nematode-specific 24-kDa protein in Ascaris suum. Parasitology 130, 131-139.
- Tsuji N, Miyoshi T, Islam MK, Isobe T, Yoshihara S, Arakawa T, Matsumoto Y, Yokomizo Y.(2004). Recombinant Ascaris 16-kDa protein-induced protection against Ascaris suum larval migration following intranasal vaccination in pigs. J Infect Dis 190, 1812-1820.
- Miyoshi T, Tsuji N, Islam MK, Kamio T, Fujisaki K. (2004). Gene silencing of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis by using RNA interference. J Vet Med Sci 66, 1471-1473.
- Miyoshi T, Tsuji N, Islam MK, Kamio T, Fujisaki K. (2004). Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis. J Vet Med Sci 66,1195-1198.
- Miyoshi T, Tsuji N, Islam MK, Kamio T, Fujisaki K. (2004). Cloning and molecular characterization of a cubilin-related serine protease from the hard tick Haemaphysalis longicornis. Insect Biochem Mol Biol 34, 799-808.
- Islam MK, Miyoshi T, Yokomizo Y, Tsuji N. (2004). The proteome expression patterns in adult Ascaris suum under exposure to aerobic-anaerobic environment analyzed by two-dimensional electrophoresis. Parasitol Res 93, 96-101.
- Islam MK, Miyoshi T, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y, Tsuji N. (2003). Temperature and metal ions-dependent activity of the family I inorganic pyrophosphatase from the swine roundworm Ascaris suum.J Vet Med Sci 66,221-223.
- Tsuji N, Suzuki K, Kasuga-Aoki H, Isobe T. Arakawa T, Matsumoto Y. (2003). Mice Intranasally immunized with a recombinant 16-kilodalton antigen from the roundworm Ascaris parasites are protected against larval migration of Ascaris suum. Infect Immun 71, 5314-5322.
- Islam MK, Miyoshi T, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y, Tsuji N. (2003). Inorganic pyrophosphatase in the roundworm Ascaris is essential for the development and molting process of the larval stage parasites. Eur J Biochem 270, 2814-2826.
- Arakawa T, Tsuboi T, Kishimoto A, Sattabongkot J, Suwanabun N, Rungruang T, Matsumoto Y, Tsuji N, Hisaeda H, Stowers A, Shimabukuro I, Sato Y, Torii M. (2003). Serum antibodies indudced by intranasal immunization of mice with Plasmodium vivax Pvs25 co-administrated with cholera toxin completely block parasite transmission to mosquitoes. Vaccine 21, 3143-3148.
- You M, Xuan X, Tsuji N, Kamio T, Taylor D, Suzuki N, Fujisaki K. (2003). Identification and molecular characterization of a chitinase from the hard tick Haemaphysalis longicornis. J Biol Chem 278, 8556-8563.
- Tsuji N, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y. (2002). Cloning and characterisation of a highly immunoreactive 37 kDa antigen with multi-immunoglobulin domains from the swine roundworm Ascaris suum. Int J Parasitol 32, 1739-1746.
- Wossene A, Tsuji N, Kasuga-Aoki H, Miyoshi T, Isobe T, Arakawa T, Matsumoto Y, Yoshihara S. (2002). Lung stage protein Profile and antigenic relationship between Ascaris lumbricoides and Ascaris suum. J Parasitol 88, 826-828.
- Wossene A, Tsuji N, Kasuga-Aoki H, Miyoshi T, Isobe T, Arakawa T, Matsumoto Y, Yoshihara S. (2002). Species specific proteins identified in Ascaris lumbricoides and Ascaris suum using two-dimensional electrophoresis. Parasitol Res 88, 868-871.
- Kadota K, Satoh E, Ochiai M, Inoue N, Tsuji N, Igarashi I, Nagasawa H, Mikami T, Claveria FG, Fujisaki K. (2002). Existence of phenol oxidase in the argasid tick Ornithodoros moubata. Parasitol Res 88, 781-784.
- Ikadai H, Nagai A, Xuan X, Kamio T, Tsuji N, Oyamada T, Suzuki N, Fujisaki K. (2002). Seroepidemiologic studies on Babesia caballi and Babesia equi infections in Japan. J Vet Med Sci 64, 325-328.
- Kabamoto S, Bhagat NA, Suzuki H, You M, Kamio T, Tsuji N, Claveria FC, Nagasawa H, Igarashi I, Toyoda Y, Fujisaki K. (2002). Comparison of macrophage scavenger receptor-A knockout mice with wild type ones in the immune response against repeated infestation with Haemaphysalis longicornis. J Vet Med Sci 64, 355-359.
- Kasuga-Aoki H, Tsuji N, Suzuki K, Matsumoto Y, Arakawa T, and Isobe T. (2002). Molecular characterization of a glyceraldehydes-3-phosphate dehydrogenase from the swine roundworm Ascaris suum. Mol Biochem Parasitol 119,135-139.
- Tsuji N, Suzuki K, Kasuga-Aoki H, Matsumoto Y, Arakawa T, Ishiwata K, and Isobe T. (2001). Intranasal immunization with recombinant Ascaris suum 14-kilodalton antigen coupled with cholera toxin B subunit induces protective immunity to A. suum infection in mice. Infect Immun 69, 7285-7292.
- You M, Xuan X, Tsuji N, Kamio T, Igarashi I, Nagasawa H, Mikami T, Fujisaki K. (2001). Molecular characterization of a troponin I-like protein from the hard tick Haemaphysalis longicornis. Insect Biochem Mol Biol 32, 67-73.
- Inoue O, Honda K, Tsuji N, Igarashi I, Nagasawa H, Mikami T, Fujisaki K. (2001). Characterization of phagocytic hemocytes in Ornithodoros moubata (Acari: Ixodidae). J Med Entomol 38, 514-519.
- Kasuga-Aoki H, Tsuji N, Suzuki K, Matsumoto Y, Arakawa T and Isobe T. (2001). Identification of larval-stage antigens of Ascaris suum recognized by immune sera from pigs. J Vet Med Sci 63, 683-685.
- Kawazu S, Komaki K, Tsuji N, Kawai S, Ikenoue Y, Hatabu T, Ishikawa H, Matsumoto Y, Himeno K, Kano S. (2001). Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol 116, 73-79.
- Tsuji N, Kamio T, Fujisaki K. (2001). Molecular characterization of a peroxiredoxin from the hard tick Haemaphysalis longicornis. Insect Mol Biol 10, 121-129.
原著論文(2000年以前)
- Tsuji N, Morales T, Ozols V, Carmody A, Chandrashekar R. (2000). Cloning and preliminary characterization of a novel cuticular antigen from the filarial parasite Dirofilaria immitis. Parasitol Int 86, 200-206.
- Kawazu S, Tsuji N, Hatabu T, Kawai S, Matsumoto Y, Kano S. (2000). Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol 109,165-169.
- Kasuga-Aoki H, Tsuji N, Isobe T, Yoshihara S. (2000). Identification of surface proteins and antigens from larval stages of Ascaris suum by two-dimensional electrophoresis. Parasitology 121,671-677.
- Tsuji N*, Kasuga-Aoki H, Isobe T, Yoshihara S. (2000). Cloning and characterization of a thioredoxin peroxidase from the swine roundworm Ascaris suum. Int J Parasitol 30, 125-128.
- Osaki M, Takamatsu D, Tsuji N, Sekizaki T. (2000). Cloning and characterization of the gene encoding O-acetylserine lyase from Streptococcus suis. Curr Microbiol 40, 67-71.
- Chandrashekar R, Tsuji N, Morales T, Ozols V, Welton J, Tang L. (2000). Cloning and characterization of a 1-Cys peroxiredoxin from the filarial parasite Dirofilaria immitis. Parasitol Res 86, 200-206.
- Numajiri M, Tsuji N, Kasuga-Aoki H, Isobe T. (2000). Biotin labeled proteins of Eimeria tenella sporozoites. J Vet Med Sci 62, 357-359.
- Tsuji N, Ohta M, Kawazu S, Kamio T, Isobe T, Shimura K, Fujisaki K. (1999). DNA polymorphism of srRNA gene among Eimeria tenella strains isolated in Japan. J Vet Med Sci 61, 1331-1333.
- Tsuji N, Morales T, Ozols V, Carmody A, Chandrashekar R. (1999). Identification of an asparaginase amidohydrolase from the the filarial parasite Dirofilaria immitis. Int J Parasitol29, 1447-1449.
- Tsuji N, Morales T, Ozols V, Carmody A, Chandrashekar R. (1998). Molecular characterization of a calcium-binding protein from the filarial parasite Dirofilaria immitis. Mol Biochem Parasitol 97, 69-79.
- Chandrashekar R, Tsuji N, Morales T, Ozols V, Mehta K. (1998). An ERp-60-like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide activity. Proc Natl Acad Sci USA 95, 531-536.
- Tsuji N, Kawazu S, Ohta M, Kamio T, Isobe T, Shimura K, Fujisaki K. (1997). Discrimination of eight chicken Eimeria species using the two-step polymerase chain reaction. J Parasitol 83, 966-970.
- Daubenberger C, Heussler V, Gobright E, Wijngaard P, Clevers HC, Wells C, Tsuji N, Musoke A, McKeever D. (1997). Molecular characterisation of a cognate 70 kDa heat shock protein of the protozoan Theileria parva. Mol Biochem Parasitol 85, 265-269.
- Tsuji N, Ohta M, Fujisaki K. (1997). Expression of a 70-kDa heat-shock-related protein during transformation from free-living infective larvae to the parasitic stage in Strongyloides venezuelensis. Parasitol Res 83, 99-102.
- Ohta M, Kawazu S, Tsuji N, Terada H, Kamio T, Fujisaki K. 1996. DNA probes for detection Babesia ovata or the Babesia sp1, a newly isolated Bovine Babesia parasite in Japan. J Protozool Res 5: 58-68.
- Ohta M, Kawazu S, Tsuji N, Terada H, Kamio T, Fujisaki K. (1996). Rapid and sensitive methods for detection of a newly isolated Bovine Babesia parasite (B. sp1) in the anticipated vector-tick using the polymerase chain reaction. J Protozool Res 5, 108-117.
- Ohta M, Tsuji M, Tsuji N, Fujisaki K. (1995). Morphological, serological and antigenic characteristics, and protein profile of newly isolated Japanese bovine Babesia parasite with particular reference to those of B. ovata. J Vet Med Sci 57, 671-675.
- Tsuji N, Fujisaki K. (1994). Development in vitro of free-living infective larvae to the parasitic stage of Strongyloides venezuelensis by temperature shift. Parasitology 109, 643-648.
- Chandrawathani P, Tsuji N, Kawazu S, Ishikawa M, Fujisaki K. (1994). Seroepidemiological studies of bovine babesiosis caused by Babesia ovata, B. bigemina and B. bovis in Peninsular Malaysia. J Vet Med Sci 56, 929-932.
- Zakimi S, Tsuji N, Fujisaki K. (1994). Protein analysis of Anaplasma marginale and Anaplasma centrale by two-dimensional polyacrylamide gel electrophoresis. J Vet Med Sci 56, 1025-1027.
- Nakamura Y, Tsuji N, Taira N. (1994). Wasting condition under normal cardiac rhythms in rabbits following Strongyloides papillosus infection. J Vet Med Sci 56, 1005-1007.
- Nakamura Y, Tsuji N, Taira N, Hirose H. (1994). Parasitic females of Strongyloides papillosus as a pathogenetic stage for sudden cardiac death in infected lambs. J Vet Med Sci 56, 723-727.
- Tsuji N, Kawazu S, Nakamura Y, Fujisaki K. (1993). Protein analysis of Strongyloides venezuelensis by two-dimensional polyacrylamide gel electrophoresis. J Vet Med Sci 55, 881-883.
- Ura S, Taira N, Nakamura Y, Tsuji N, Hirose H. (1993). Sudden death of calves by experimental infection with Strongyloides papillosus. IV. Electrocardiographic and pneumographic observations at critical moments of the disease. Vet Parasitol 47, 343-347.
- Tsuji N, Nakamura Y, Taira N. (1993). Long-lasting parasitism of Strongyloides venezuelensis in Mongolian gerbils (Meriones unguiculatus). J Parasitol 79, 305-307.
- Nakanishi N, Nakamura Y, Ura S, Tsuji N, Taira N, Tanimura N, Kubo M. (1993). Sudden death of calves by experimental infection with Strongyloides papillosus. III. Hematological, biochemical and histological examinations. Vet Parasitol 47, 67-76.
- Tsuji N, Itabisashi T, Nakamura Y, Taira N, Kubo M, Ura S, Genno A. (1992). Sudden cardiac death in calves with experimental heavy infection of Strongyloides papillosus. J Vet Med Sci 54, 1137-1143.
- Taira N, Ura S, Nakamura Y, Tsuji N. (1992). Sudden death of calves infected with Strongyloides papillosus. Japan Agr Res Quart 26, 203-211.
- Ura S, Nakamura Y, Tsuji N, Taira N. (1992). Sudden death of calves by experimental infection with Strongyloides papillosus. II. Clinical observations and analysis of critical moments of the disease recorded on videotape. Vet Parasitol 44, 107-110.
- Taira N, Nakamura Y, Tsuji N, Kubo M, Ura S. (1992). Sudden death of calves by experimental infection with Strongyloides papillosus. I. Parasitological observations. Vet Parasitol 42, 247-256.
特許
- 辻 尚利、藤崎幸蔵、黄暁紅、三好猛晴.
ベクターマダニのガレクチン、それをコードする核酸分子及びそれらの利用.
特許公開2007-37464. - 藤崎幸蔵、玄 学南、八田岳士、辻 尚利.
マダニのロイシンアミノペプチダーゼ.
特許公開2006-246747. - 新川 武、只野昌之、島袋 勲、佐藤良也、松本安喜、辻 尚利.
ヘテロ型5量体組換えワクチン.
特許公開2005-052135. - 辻 尚利、神尾次彦、三好猛晴、藤崎幸蔵、バトツェツェグ バダガル.
ピロプラズマ原虫殺虫作用を有するペプチド蛋白質、それをコードする核酸分子及びそれらの利用.
特許3803733. - 辻 尚利、磯部 尚、春日春江、カイルル イスラム、新川 武、松本安喜.
寄生虫の無機ピロホスファターゼ、それをコードする核酸分子及びそれらの利用.
特許公開2004-081032. - 新川 武、鳥居本美、坪井敬文、只野昌之、松本安喜、辻 尚利、島袋 勲、佐藤茂俊、長嶺 勝.
マラリア原虫伝搬阻止粘膜ワクチン.
特許公開2003-277292. - 只野昌之、新川 武、馬 紹平、 福永利彦、佐藤良也、松本安喜、辻 尚利、倉根一郎、森田公一.
日本脳炎ワクチンによる西ナイルウイルスの感染に対する交叉防御.
特許公開2003-313140. - 藤崎幸蔵、ユウ・ミョンジョ、長澤秀行、五十嵐郁男、鈴木宏志、杉本千尋、玄 学南、辻 尚利.
ダニのキチナーゼ.
WO03/072609. - 辻 尚利、磯部 尚、春日春江、新川 武、 松本安喜.
豚回虫 (Ascaris suum)感染幼虫の14kDa抗原、それをコードする核酸分子及びそれらの利用.
特許3692396. - 藤崎幸蔵、門田君江、長澤秀行、五十嵐郁男、鈴木宏志、杉本千尋、玄 学南、辻 尚利.
ダニのガレクチン.
WO03/072781. - 新川 武、只野昌之、松本安喜、辻 尚利、佐藤良也、福永利彦、佐藤茂俊、長嶺 勝、倉根一郎.
日本脳炎ワクチンをコードする遺伝子を含むトランスジェニック植物.
特許公開2003-116385. - 辻 尚利、磯部 尚、春日春江、松本安喜、新川 武.
豚回虫(Ascaris suum)感染幼虫の16kDa抗原、それをコードする核酸分子及びそれらの利用.
特許3613577. - 新川 武、只野昌之、松本安喜、辻 尚利、佐藤良也、福永利彦、佐藤茂俊、長嶺勝、倉根一郎.
不活化日本脳炎ウイルス及びウイルス由来の組換えタンパク質の経粘膜投与法による全身免疫応答の誘導ならびに感染防御効果.
特許公開2003-117141. - 辻 尚利、藤崎幸蔵、神尾次彦.
ダニのペルオキシレドキシンおよびそれをコードする核酸分子とその利用.
特許公開2002-010785. - 藤崎幸蔵、ユーミョンジョ、長沢秀行、五十嵐郁夫、鈴木宏志、杉本千尋、玄 学南、辻 尚利.
ダニのトロポニンI及びそれをコードする核酸分子及びそれらの利用.
特許公開2002-112778. - 大田方人、藤崎幸蔵、神尾次彦、寺田 裕、河津信一郎、辻 尚利.
バベシア・オバタに特異的な塩基配列とそれを利用したバベシア・オバタ検出方法.
特許3103882. - Ramaswany Chandrashekar, Naotoshi Tsuji.
Dirofilaria and Brugia thioredoxin peroxidase type-2 (TPX-2) nucleic acid molecules, and uses thereof.
United States Patent Pat. No. 6,150,135. - Ramaswany Chandrashekar, Naotoshi Tsuji.
Parasitic helminth asparaginase proteins, nucleic acid molecules and uses thereof.
United States Patent Pat. No. 6,165,735.

